Hāʻawi mākou i ka 5- Azacytidine API

Haʻaheo mākou e hāʻawi 5- Azacytidine API, he lāʻau lapaʻau kūlana kiʻekiʻe i hoʻohana ʻia ma ke ʻano he antineoplastic a antiviral agent. Hoʻohana nui ʻia kēia API i ka mālama ʻana i ka maʻi leukemia myeloid acute, myelodysplastic pattern, a me ka maʻi maʻi myelomonocytic maʻamau. Hana ʻia kā mākou huahana e like me nā kūlana koʻikoʻi koʻikoʻi, icing i kona chastity a me ka pono. Loaʻa iā ia i loko o ka nui o ka pahu waihoʻoluʻu e kūpono i kou kūlana kikoʻī. E hilinaʻi iā mākou e hāʻawi iā ʻoe me ka ikaika hilinaʻi a me ka ikaika o 5- Azacytidine. e kamaʻilio mai iā mākou i ka manawa e aʻo hou ai e pili ana i kēia huahana a pehea e hiki ai iā mākou ke kōkua iā ʻoe.

He aha ka Azacytidine?

5- ʻO Azacytidine ka lehu, ʻike ʻia ʻo Azacitidine a i ʻole 5-AC, he mea kemika. He analog nucleoside i hana ʻia me kahi kumu adenine a me kahi ʻāpana apo i koho ʻia i ka heterocycle nitrogen i loaʻa i ka nitrogen. He waiwai DNA methyltransferase a hoʻohana mau ʻia e mālama i ke ʻano myelodysplastic (MDS), he maʻi koko. ʻO kona inoa kemika ʻo 4- Amino- 1-(- D-ribofuranosyl) (1H)- hoʻokahi, a ʻo kāna helu CAS 320-67-2. ʻO C8H12N4O5 kona ʻano kemika, a ʻo kona kaumaha molekala he 244.2 g/ spook. Hiki iā ia ke hoʻololi i ka hōʻike gene a loaʻa nā pōmaikaʻi hoʻoponopono i nā kūlana e like me ka myelodysplastic pattern (MDS) ma o ka snooping me ke kaʻina hana methylation DNA. Ma ka pale ʻana i ka hoʻololi ʻana i ka DNA methylation, hoʻoikaika ia i ka ulu ʻana o nā cell hematopoietic olakino a hoʻohuli i ka conformation o nā cell hematopoietic kūpono ʻole.

ʻO ka loaʻa ʻana o ka ʻike ʻana o 5-Azacytidine mai ka makahiki 1950. Hiki ke ʻike ʻia kahi ʻike o kāna mau ʻike ma aneʻi:

ka mua Azacytidine API Ua hoʻokō ʻia ka hui ʻana i ka makahiki 1958 e nā mea hoʻokolohua mai ka Chemical Development Section o nā National Institutes of Health ma ʻAmelika Hui Pū ʻIa. Ua hoʻonohonoho lākou i kēia mea i kāohi i ka methylation o ka DNA cellular.

Ua hoʻomaka ka National Cancer Institute (NCI) ma ʻAmelika Hui Pū ʻIa i ka ʻimi hou ʻana ma azacytidine ma 1964.

ʻO ka pauka Azacitidine ua hala i ka ʻimi a me ka hoʻomohala hou i nā makahiki i hala. Ua hāʻawi ka US Food and Drug Administration (FDA) i ka hoʻomaikaʻi ʻana iā Azacytidine (ua kūʻai ʻia ʻo Vidaza) i ka makahiki 1985 no ka hana ʻana o ka myelodysplastic pattern (MDS). ʻO ka hopena, ua hoʻohana mau ʻia e mālama i ka MDS pū kekahi.

kumu o Information

Ka inoa huahana: 5-Azacytidine
CAS:320-67-2
MF:C8H12N4O5
MW:244.2
EINECS: 206-280-2
MDL Helu.:MFCD00006539
Maʻemaʻe: 99%
Paʻa: Paʻa no 2 mau makahiki
hiki ke hoʻoheheʻe ʻia: Hiki ke hoʻoheheʻe ʻia ma DMSO (a hiki i 25 mg/ml), a i ʻole i ka wai (a hiki i 12 mg/ml).
Hoʻohana: Papa lāʻau lapaʻau a hoʻohana ʻia no ka noiʻi.
Packaging: E ​​like me kāu noi
Waihona: lumi lumi.
Kumu hoʻolālā:

Ka helu hehee: 226 a 232 ℃

Puni paila: 534.5 ℃

Hiki ke hoʻoheheʻe wai: soluble

Māmā: 2.08 g/cm ³

Kekahi uila: 277 ℃

ʻO ke kūlana maikaʻi

Hoʻopili: 500g / ʻeke; 1kg / ʻeke

Nā kūlana mālama: -20 ℃, hōʻoiaʻiʻo, hoʻopaʻa ʻia, a me ka hōʻoia māmā

Nā kūlana hoʻokele: 2-8 ℃ ka halihali

Māhele: Nā mea ʻawaʻawa

Hoʻokaʻawale ʻana i nā mea ʻawaʻawa: ʻona loa

ʻona ʻawaʻawa: waha LD50 i nā ʻiole: 572 mg/kg; ʻIole ʻōpū o ka ʻōpū LD50: 68 mg/kg

ʻO nā hiʻohiʻona pōʻino o ke ahi: hiki ke puhi ʻia; Hoʻopuka ka puhi ʻana i ka uahi nitrogen oxide ʻona; Nā hopena ʻaoʻao o ka lāʻau lapaʻau no ka poʻe maʻi: nausea, luaʻi, maʻi maʻi, a me ka emi ʻana o ke koko keʻokeʻo

Mea hoʻopau: ka pauka maloʻo, ka huʻa, ke one, carbon dioxide, ka wai ʻātoma

He aha ka noi o 5-Azacytidine pauka ?

Eia na mea nui e hoohana ai 5-Azacytidine pauka a me kona mau wahi noi:

1. Nā lāʻau antimetabolic

ʻO ka hōʻailona nui ʻo ka maʻi leukemia myeloid acute ʻaʻole kūpono i ka mālama maʻamau. Hoʻohana ʻia ia no ka maʻi maʻi umauma, melanoma, maʻi ʻōpū, a me nā mea ʻē aʻe. ʻO ka nausea a me ka luaʻi he mau hopena ʻino maʻamau, hiki ke hoʻomaikaʻi ʻia e ka infusion lōʻihi a i ʻole ka hoʻohana ʻana i nā antiemetics 24 a 48 mau hola ma mua o ka mālama ʻana. ʻO nā hopena ʻawaʻawa ʻē aʻe e pili ana i ka maʻi maʻi, nā maʻi neuromuscular, ke kuni, ka hypotension, a me ka ʻeha. Hoʻomākaukau hou ʻia ka hoʻolālā 3-4 mau hola ma mua o ka hoʻohana ʻana.

2. He mea hoʻoulu ulu ikaika a me ka cytotoxic agent

Hoʻopaʻa ʻia o DNChemicalbookA methyltransferase, kahi ʻano hoʻoponopono koʻikoʻi no ka hōʻike ʻana o ke ʻano, hoʻāla, a me ka silencing; ʻO nā mea hoʻopau i ka maʻi kanesa me ka hana antibody nāwaliwali (Gram positive); Hoʻohana ʻia e aʻo i ka hopena o ka hoʻohui ʻana o DNA i ka wā DNA methylation kaʻina

3. He mea hiki ke hoʻoulu i ka ulu a me ka mea lawe cytotoxic

Ke kāohi nei i ka DNA methyltransferase, he ʻano hoʻoponopono koʻikoʻi ia no ka hōʻike ʻana i ke ʻano, ka hoʻoulu ʻana o ke ʻano, a me ka pani ʻana i ke ʻano. ʻO kēia kumu ke kumu o ka DNA demethylation a i ʻole semi demethylation, e ʻae ana i nā mea transcription e hoʻopaʻa i ka DNA a hoʻāla hou i nā genes suppressor tumor.

ʻIke palekana

Lepili waiwai ʻino: T

Kiʻi waeʻano pōʻino: 45-46-22

Safety instructions: 53-22-36/37/39-45

WGK Kelemānia: 3

Helu RTECS: XZ3017500

F: 10-23

Pāʻālua dute: 29349990

ʻIkepili meaʻawaʻawa: 320-67-2

Kaʻawaʻawa: LD50 i nāʻiole (mg / kg): 115.9 ip; 572.3 waha (Palm, Kensler)

ʻO ka hana hoʻomōmaʻai

ʻO Azacytidine Hoʻohana ʻo ia i kāna hopena anti-tumor ma o ka hoʻemi ʻana i ka methylation DNA a me ka hoʻohana ʻana i ka cytotoxicity pololei ma nā pūpū hematopoietic abnormal. Ua hōʻike ʻia nā haʻawina in vitro ʻo ka neʻe ʻana o kēia huahana i ka palena nui o ka methylation DNA ʻaʻole ia e pale nui i ka synthesis DNA. Hiki i ke ʻano o ka methylation haʻahaʻa ke hoʻihoʻi i ka hana maʻamau o nā genes pili kokoke i ka ʻokoʻa a me ka hoʻonui ʻana o nā puke kemika maikaʻi. ʻO ka hopena cytotoxic o kēia huahana hiki ke make i nā pūnaewele e hoʻomāhuahua wikiwiki ana, e komo pū ana me nā maʻi maʻi maʻi i nalowale i ka mana hana maʻamau, aʻo nā cell non proliferating ʻaʻole i pili i kēia huahana. Nānā, nā waiwai physicochemical, nā ʻano hoʻomākaukau, nā hopena pharmacological, a me nā noi o azacitidine

ko kakou pono

ʻIke waiwai: loaʻa iā mākou he 13 mau makahiki o ka ʻike ʻoihana;

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I ka hōʻuluʻuluʻana, ma keʻano heʻoihana Azacitidine API mea hana, loaʻa iā mākou ka ʻenehana kiʻekiʻe, ka waiwai nui, ka maikaʻi maikaʻi loa, ka ʻike hana waiwai, a me nā lawelawe maikaʻi loa. ʻO kēia mau pōmaikaʻi ka mea e kū ai i ka hoʻokūkū mākeke a lanakila i ka hilinaʻi a me ke kākoʻo o nā mea kūʻai aku.

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