He aha ka Actinomycin D?

ʻO Actinomycin D, ʻike ʻia ʻo Dactinomycin a i ʻole Actinomycin, ʻo ia kekahi o nā antibiotic peptide koʻikoʻi i ka papa actinomycin insulated mai Streptomyces bacteria i hoʻonohonoho ʻia i loko o ka lepo. ʻO ia kekahi o nā mea lapaʻau chemotherapeutic mua, a ua hoʻohana ʻia no ka manawa lōʻihi loa. ʻO ia ka lāʻau antibiotic mua me nā waiwai anticancer i ʻike ʻia e nā kānaka. SelmanA. Waksman a me kona hoaH.B. Ua ʻike mua ʻia ʻo Woodruff i ka makahiki 1940. Ua hoʻokomo ʻia ʻo Dactinomycin ma ke noi e Merck ma lalo o ka inoa inoa Cosmegen ma hope o ka hāʻawi ʻia ʻana e ka FDA ʻAmelika i ka lā 10 Dekemaba, 1964. Loaʻa iā ia ka hiki ke hoʻopaʻa i ka DNA ma ka recap inauguration complex, e hana ana i kahi paʻakikī me ka DNA a me ka hoʻopili ʻana i ka hiki o ka RNA polymerase e synthesize RNA. Loaʻa iā ia ka hiki ke hoʻopaʻa i ka DNA stranded ʻelua, kahi e hiki ai iā ia ke kāohi i ka huahana RNA me ka loaʻa ʻana o ka hopena i ka hoʻopiʻi DNA. Eia naʻe, hoʻohana maʻamau ka poʻe ʻepekema i kekahi mau pilikia replication DNA, e like me ka hydroxyurea, i kūpono no ka hoʻohana ʻana i ke keʻena. I ka ʻimi ʻana e pili ana i ka inflow cytometry a me ka haʻawina bitsy o nā cell, Actinomycin D pauka a me kāna hua fluorescent, 7- aminoactinomycin D (7-AAD), hoʻohana ʻia e like me nā stains.

Ua kūpono lākou no ka hōʻailona DNA ma muli o ko lākou pilina no nā ʻāpana DNA waiwai GC. No ka mea hiki i ka 7-AAD ke hoʻopili i ka DNA stranded hoʻokahi, he mea maikaʻi hoʻi ia no ka nānā ʻana i ka apoptosis cell a haʻi i nā cell ola ma waho o nā mea make.

kumu o Information

Ka inoa huahana: Actinomycin D

He inoa ʻē aʻe: Actinomycin D, Actinomycin IV, Actinomycin C1, Dactinomycin; Actinomycin A IV; actinomycin7; actinomycinaiv

CAS:50-76-0

MF:C62H86N12O16

MW:1255.42

EINECS: 246-818-3

Kuhi hoʻoheheʻe: 251-253 ℃

Hiki ke hoʻoheheʻe ʻia: ethanol, DMSO: Paʻa i loko o nā haʻina wai ma 2-8 ℃ hiki ke hoʻoheheʻe ʻia.

ka mahana mālama. 2-8 ℃

Paʻa: Paʻa

Kumu hoʻolālā:

ʻO ke kūlana maikaʻi

Launch

ʻO Actinomycin D  he nui nā hopena:

1. Ka hopena anticancer: ʻO ka lāʻau lapaʻau mua me nā ʻano anticancer e ʻike ʻia e nā kānaka ʻo actinomycin D. Hoʻopaʻa ʻo ia i ka DNA a pale i ka RNA polymerase mai ka hana ʻana i ka RNA, e pale ana i nā cell excrescence mai ka hoʻonui a hoʻonui.

2. Ka hopena anti-inflammatory: loaʻa iā ia ka hopena ananti-inflammatory ma ke kāohi ʻana i nā pane kipi a me ka hoʻoikaika ʻana o ka ʻōnaehana. Hoʻohaʻahaʻa kēia i ka hoʻokuʻu ʻana o nā mea uwao hoʻomāinoino a hoʻemi i nā hōʻailona pili i ka mumū a me ka pōʻino o ke kāwele.

3. Immunosuppressive hopena: he immunosuppressive hopena ma o ka ho'ēmiʻana i ka proliferation a me ka hana o ka vulnerable cell a me ka pale 'ana i ka vulnerable'ōnaehana hiki ke hana i nā antibodies. I ka lāʻau immunosuppressive ma hope o ka hoʻololi ʻana o ke kino, hoʻohana ʻia ia.

4. Ka hopena Antiviral: loaʻa iā ia nā waiwai antiviral e hoʻoikaika ai i nā maʻi maʻi. Hiki iā ia ke ho'ōki i ka laha a me ka hoʻonui ʻana i nā maʻi maʻi.

5. Ka hopena antibacterial: loaʻa iā ia kahi hana antibacterial e hana kūʻē i kekahi mau microorganism. Loaʻa iā ia ka hiki ke hoʻopau i ka ulu ʻana o ka bacteria a me ka hoʻonui hou ʻana.

He mea koʻikoʻi ia e hoʻihoʻi i hope he lāʻau koʻikoʻi ia a pono e hoʻohana wale ʻia ma lalo o ka mākaʻikaʻi a croaker a me ka akahele. I mea e hōʻoiaʻiʻo ai i ka palekana a me ka pono, pono ke koho ʻia ka lozenge a me ke ʻano o ka hoʻoponopono ʻana ma muli o nā kūlana kūʻokoʻa.

noi

ʻO nā noi o ʻO Dactinomycin puke:

1. Hoʻohana mau ʻia ka lāʻau lapaʻau lāʻau lapaʻau mua ʻo actinomycin D i loko o nā hoʻonohonoho lapaʻau no ka mālama ʻana i nā ʻano maʻi maʻi ʻino like ʻole, me ka excrescences solid pediatric, Wilms excrescence, rhabdomyosarcoma, a me hepatocellular melanoma.

2. Immunosuppressive therapy: hoʻohana ʻia ia i ka lāʻau immunosuppressive ma hope o ka hoʻololi ʻana o ke kino no ka mea hiki iā ia ke pale i ka ʻōnaehana nāwaliwali. Hoʻonui ia i ka holomua o ka hoʻololi ʻana a kōkua i ka hoʻohaʻahaʻa ʻana i ka pane hōʻole ʻana i nā kino i hāʻawi ʻia.

3. ʻO nā maʻi ʻaʻai: ʻo ia ka anti-inflammatory rate e kūpono ia no ka mālama ʻana i kekahi mau kūlana kipi, me ka rheumatoid arthritis a me ka hoʻopiʻi ʻana i ka ʻōpū.

He mea koʻikoʻi ia e ʻike hiki iā ia ke hoʻoulu i nā hopena maikaʻi ʻole e like me ka hana ʻole o ka ate, nā pilikia ʻōpū, a me ka hoʻopau ʻana i ka iwi iwi. No laila, ma mua o ke kuhikuhi ʻana Actinomycin-d, loiloi nā kauka lapaʻau i nā hōʻailona o ka mea maʻi a hana i nā regimens lapaʻau kūikawā ma muli o ko lākou kūlana kūʻokoʻa. He mea koʻikoʻi ka hoʻohana ʻana i ka Actinomycin D ma lalo o ke kiaʻi a ke kauka a mālama i kā lākou mau ʻōlelo aʻoaʻo a me nā hana palekana.

Paʻa a mālama

ʻO ke kūlana kūpaʻa a me ka mālama ʻana o ia mea penei:

1. Ka wela o ka mālama ʻana: No ka mālama ʻana i kona kūpaʻa, pono e mālama ʻia i nā mahana maloʻo (-20 degere Celsius). Hiki ke manaʻo ʻia e mālama ʻia i nā mahana haʻahaʻa no ka mālama lōʻihi, e like me -80 degere Celsius.

2. Palekana māmā: pono e mālama ʻia i loko o nā kūlana e pale ai i ka mālamalama a noho i waho o ka lā pololei ma muli o kona ʻike i ka mālamalama. No ka hoʻemi ʻana i ka hopena o ka mālamalama i ka lāʻau lapaʻau, hiki ke hoʻohana ʻia nā pahu opaque a ʻeleʻele paha no ka mālama ʻana.

3. Kaiapuni maloʻo: No ka mālama ʻana i ka makū mai ka hoʻopili ʻana i ka lāʻau lapaʻau, pono e mālama ʻia ma kahi maloʻo. No ka hōʻoia ʻana ua maloʻo ka lāʻau lapaʻau, hiki ke hoʻohana ʻia nā pahu i hoʻopaʻa ʻia a i ʻole nā ​​​​mea hoʻopili.

4. E hōʻalo i nā pōʻai maloʻo maloʻo: hiki ke emi i ka paʻa me nā pōʻai maloʻo maloʻo, no laila ʻoi aku ka maikaʻi e pale i ka hana pinepine ʻana ma mua o ka hoʻohana ʻana.

E ʻoluʻolu e nānā i kēlā Actinomycin d dmso pono e mālama ʻia i loko o nā kūlana i ʻōlelo ʻia aʻe e mālama i kona kūpaʻa a me ka pono. E nānā i ke ʻano o ka lāʻau lapaʻau a me ka lā pau ma mua o ka hoʻohana ʻana.

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Hāʻawi i nā huahana like ʻole: ua hoʻohana ʻia nā huahana i nā hōʻailona nui o ka honua ma ke ʻano o nā lāʻau lapaʻau, nā meaʻai meaʻai, nā mea hoʻonaninani, nā meaʻai holoholona a me nā meaʻai hana.

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i ka hopena

I ka hōʻuluʻuluʻana, ma keʻano heʻoihana ʻO Actinomycin D mea hana, loaʻa iā mākou ka ʻenehana kiʻekiʻe, ka waiwai nui, ka maikaʻi maikaʻi loa, ka ʻike hana waiwai, a me nā lawelawe maikaʻi loa. ʻO kēia mau mea maikaʻi e kū ai kā mākou Dactinomycin i ka hoʻokūkū mākeke a lanakila i ka hilinaʻi a me ke kākoʻo o nā mea kūʻai aku. inā pono ʻoe Actinomycin D pauka, pls e hoʻokaʻaʻike mai iā mākou i kēlā me kēia manawa. e pane mākou iā ʻoe asap.

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