2-Deoxy-D-glucose pauka mea hoolako

ʻO Xiʻan Yihui Company kahi mea hana ʻoihana ʻoi loa 2-Deoxy-D-glucose pauka. Hiki iā mākou ke hana i ka 2DG me kahi ʻike 99.9%. Hiki ke hoʻohana ʻia i ka meaʻai, ka lāʻau lapaʻau, nā mea mālama olakino, a i ʻole nā ​​mea hoʻonaninani a kū i nā kūlana USP, BP, EP, CP. Hiki iā mākou ke hāʻawi iā ʻoe i nā huahana o ka caliber kiʻekiʻe loa i nā uku hoʻokūkū. ʻO kāu koho maikaʻi loa no kahi mea hoʻolako 2DG maʻemaʻe kaulana ʻo Xiʻan Yihui Company!

He aha ka pauka 2-Deoxy-D-glucose?

2- ʻO ka pauka Deoxy- D- glucose he mea kemika, ʻo kona ʻano kemika C6H12O5 a ʻo kona kaumaha molekala he 164.16 g/ spook, kāna CAS NO. ʻo ia 154-17-6. He kōpaʻa kalapona ʻeono ia e like me ka glucose, akā nele i kahi pūʻulu hydroxyl ma ka snippet kalapona ʻē aʻe, no laila ua kapa ʻia ʻo "deoxy" glucose. He demitasse keʻokeʻo me ka haʻahaʻa haʻahaʻa i ka wai. ʻO ka 2DG kahi mea hoʻopuʻi metabolic maʻi hiki ke kāohi i ka lawe ʻana a me ka noi ʻana o ka glucose cell, e alakaʻi ana i kahi hāʻule o nā kūlana ATP i loko o nā cell.

Hoʻohana nui kēia lāʻau lapaʻau i nā cell tumor a me kekahi mau pathogens e hilinaʻi nei i ke kō i ko lākou substrate metabolic nui. ʻO ka hoʻohana ʻana i ka 2DG hiki ke hoʻopau maikaʻi i kēia mau cell e make a hoʻolohi i ko lākou ulu ulu. Hoʻohui ʻia, hoʻohana ʻia ʻo 2DG ma ke ʻano he mea hana i ka neuroscience a me ka noiʻi metabolism no ka mea hiki iā ia ke hoʻohālikelike i ke kūlana o ka pau ʻana o ka metabolic, e hōʻike ana i nā kikoʻī o nā ala metabolic cellular.

Hiki ke huli ʻia ka loaʻa ʻana o 2- Deoxy-D- glucose i ka makahiki 1950. I kēlā manawa, ua ʻike nā kānaka ʻepekema ʻAmelika ʻo Haskell Smith lāua ʻo Morris Ficher i kahi emulsion i kapa ʻia ʻo 2-deoxyglucose i ka wā e aʻo ana i nā mīkini hoʻopili glucose cell. Ma hope mai, ua ʻike kekahi kanaka ʻepekema ʻo Takashi Otsuka e hiki i ka 2-deoxy glucose ke komo i ka metabolism glucose cell a keʻakeʻa i ka hoʻokaʻawale cell i ka wā o ka hui ʻana o DNA.

Ma hope mai, ua hana nā kānaka ʻepekema i ka ʻimi hou aku 2-DG pauda a hoʻonohonoho i hiki iā ia ke pale i ka ulu ʻana o kekahi mau cell a me nā pathogens ʻoiai ka loaʻa ʻana o nā waiwai liʻiliʻi ma nā cell maʻamau.

No ka hoʻomaikaʻi ʻana i ka maikaʻi o 2DG, ua hoʻomaka nā ʻepekema i ka hoʻolālā ʻana a me ka synthesizing motes like. Ma kēia kaʻina hana, ua hoʻonohonoho lākou i ka 2DG he mea hoʻonāukiuki metabolic ʻoi aku ka maikaʻi, hiki iā ia ke pale pono i ka lawe ʻana o ka glucose cell a me ka noi. I kēia manawa, ua lilo ʻo 2DG i mea hana hoʻokolohua koʻikoʻi a me ka lāʻau lapaʻau.

kumu o Information

ʻO ke kūlana maikaʻi

Kaʻina Hana Hana

Ke kaʻina hana synthesis o 2-deoxy-D-glucose powder ʻelua mau ʻanuʻu:

Ma ka hana mua, hoʻokomo ʻia ka glucose i ka condensation Knoevenagel ma o ka hana ʻana me ka methyl vinyl ketone e hāʻawi i kahi pūhui carbonyl α,β-unsaturated.

Ma ka ʻanuʻu ʻelua, ua hoʻemi ʻia ka pūhui unsaturated i ka huahana i manaʻo ʻia 2-deoxy-D-glucose ma o ka hoʻemi hydrogenation.

Eia nā kaʻina hana pane kikoʻī:

ʻAkahi hoʻohālikelike pane ʻana:

Glucose + Methyl vinyl ketone → α,β-unsaturated carbonyl compound

ʻO ka mīkini hana pane ʻanuʻu mua:

Ma lalo o nā kūlana alkaline, hana ka glucose a me ka methyl vinyl ketone ma ke ʻano he nucleophilic reagents a hoʻokō i ka condensation Knoevenagel me ke kōkua o ka thioacetone a i ʻole ka sodium hydroxide, e hāʻawi ana i kahi pūhui carbonyl α, β-unsaturated.

Ka lua o ka hoʻohālikelike pane ʻana:

α,β-unsaturated carbonyl compound + Hydrogen kinoea + Catalyst → 2-deoxy-D-glucose

ʻO ka hana pane ʻanuʻu ʻelua:

Ma ke alo o ke kinoea hydrogen a me ka catalyst, ua hydrogenated ka- unsaturated carbonyl emulsion a hiki i ka 2- deoxy-D- glucose. Hoʻohana maʻamau ʻia kahi catalyst kumu e like me ka platinum a i ʻole ka mālama ʻana no kēia pane hydrogenation.

Pono e hoʻomaopopo he hoʻokahi wale nō kaila maʻamau no ka synthesizing 2- deoxy- D- glucose. ʻO ka ʻoiaʻiʻo, aia kekahi mau ala synthetic ʻē aʻe, e like me ka loiloi kemika o ka uracil a me ka microbial metabolism.

he mea nui loa ia i hoʻohana nui ʻia i ka lāʻau lapaʻau, biotechnology, a me ka ʻoihana meaʻai. Eia kona mau pono:

ʻAʻohe ona hopena ʻino i ke kino o ke kanaka a loaʻa iā ia kahi hopena pepehi kanaka i nā pūnaewele maʻi maʻi;

Loaʻa iā ia ka anti-virus, antifungal, anti-diabetes, anti-obesity a me nā hopena ʻē aʻe;

Hiki ke hoʻopili ʻia a hoʻololi ʻia e ke kino kanaka;

Hiki ke hoʻohana ʻia ma ke ʻano he radiolabeled reagent a i ʻole he mea hoʻoponopono DNA i ka biotechnology;

Hiki ke hoʻohanaʻia e like me ka meaʻono haʻahaʻa-calorie i kaʻoihana meaʻai;

I ka pōkole, he mea pono loa ia me nā noi like ʻole.

He aha ka hana o 2 Deoxy Glucose?

ʻO 2 deoxy glucose (2DG) he mea hoʻohālikelike glucose i nele i ka hui hydroxyl ma ke kūlana 2 o ke apo glucose. Hoʻohana maʻamau ia i ka ʻimi ʻepekema ma ke ʻano he mea hana e ʻimi ai i ka metabolism glucose a me kāna mau ala pili. Eia kekahi mau hana.

1. Lawe ʻia ka waiwai o ka glycolysis 2DG e nā cell ma o nā mea lawe glucose a phosphorylated e ka hexokinase i 2DG-6-phosphate, ʻaʻole hiki ke hoʻololi ʻia e ka glycolysis. no laila, hiki i ka 2DG ke hoʻokūkū hoʻokūkū i ka lawe ʻana i ka glucose a me ka glycolysis, ʻo ia ka hana mua i ka metabolism ikehu.

2. ʻO Debaser o autophagy ʻO Autophagy kahi mea hoʻoheheʻe cellular e kōkua i ka mālama ʻana i ka homeostasis cellular ma o ka hoʻihoʻi ʻana i nā protein a me nā organelles i hōʻino ʻia a makemake ʻole ʻia. Hoʻokomo ʻo 2DG i ka autophagy ma ke kāohi ʻana i ka pahuhopu mammalian o ke ala rapamycin (mTOR), e alakaʻi ana i ka hoʻāla ʻana o nā genes pili i ka autophagy.

3. Radiosensitizer: Loaʻa i nā maʻi maʻi ke kiʻekiʻe o ka glucose uptake a me ka glycolytic flux ma mua o nā pūnaewele maʻamau, i ʻike ʻia ʻo ka hopena Warburg. No laila, hiki i ka 2DG ke koho koho i nā keʻena maʻi maʻi i ka radiotherapy ma ke kāohi ʻana i ka glycolysis a me ka hoʻonui ʻana i nā pane koʻikoʻi cellular.

4. hiki ke hoʻoponopono i nā kūlana neurodegenerative 2DG ua hōʻike ʻia e hoʻomaikaʻi i ka hana cognitive a hōʻemi i ka neuropathology i nā ʻano holoholona o ka hoʻopiʻi a Alzheimer a me ka hoʻopiʻi ʻana o Parkinson. Hiki paha kēia i ka hoʻonui ʻana i ka metabolism glucose i loko o ka lolo, e hōʻemi ana i ka mumū neuronal a me ke kaumaha oxidative.

5. Mea hana no ka hoʻopaʻa inoa ʻana ma muli o kona ʻano like me ka glucose a me ka hiki ke hoʻohui i loko o ka glycolysis, 2-deoxy-d-glucose API Hiki ke hoʻohana ʻia ma ke ʻano he hōʻailona metabolic e aʻo ai i ka hopena metabolic o nā motes i unuhi ʻia i ka glucose i loko o nā cell a me nā apkins.

I ka hōʻuluʻuluʻana,2-deoxy d glucose He nui nā hana koʻikoʻi i ka noiʻi ʻepekema, ʻo ia hoʻi he mea hoʻopaneʻe i ka glycolysis, kahi mea hoʻoulu o autophagy, radiosensitizer, kahi hiki ke hoʻōla no nā maʻi neurodegenerative, a me kahi mea hana no ka hōʻailona metabolic. Loaʻa ka hopena o kāna mau noi no ka ʻepekema kumu a me ka lāʻau lapaʻau.

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i ka hopena

I ka hōʻuluʻuluʻana, ma keʻano heʻoihana 2-Deoxy-D-glucose pauka mea hana, loaʻa iā mākou ka ʻenehana kiʻekiʻe, ka waiwai nui, ka maikaʻi maikaʻi loa, ka ʻike hana waiwai, a me nā lawelawe maikaʻi loa. ʻO kēia mau pōmaikaʻi ka mea e kū ai i ka hoʻokūkū mākeke a lanakila i ka hilinaʻi a me ke kākoʻo o nā mea kūʻai aku.

Inā makemake ʻoe e ʻike hou e pili ana 2-DG a makemake paha e kūʻai, hiki iā ʻoe ke hoʻokaʻaʻike mai iā mākou i kēlā me kēia manawa. E pane koke mākou iā ʻoe ma hope o ka ʻike ʻana i ka leka.

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